Aggasztóan növekedett a gyógyszereknek ellenálló HIV-megbetegedések száma

Helyes. Elvégre az a" dolga" a vétkeinkért kapott büntetésnek, hogy ne lehessen megúszni.

tessékilyenkor belinkelni a forrást is: https://www.nature.com/articles/s41467-019-10884-9 és így teljes a kép: Our study is not without limitations. As with any observational study, the reported associations cannot be assumed to reflect causal relationships. They must be interpreted cautiously because of the potential for unmeasured confounding factors. However, the extensive data of the underlying SHCS did allow us to correct for many known and suspected confounding factors. This study examined over 1000 well-characterized HIV-1 infected individuals with 3–4 samples per individual. The number of cells per sample, however, was insufficient for further dissection of the various CD4+ cell subsets58,59. We modeled the HIV-1 reservoir decay as linear on the log10 scale based on three time points. Together with potential assay and within-subject sample variability, this indicates some uncertainty around individual slopes. Despite these and other potential limitations (e.g., not differentiating between replication competent- and -defective viruses), our study shows that total HIV-1 DNA measured in PBMC is a robust proxy for the latent HIV-1 reservoir size after the first rapid decay following initiation of ART for several reasons. It correlates independently with time to initiation of ART, with pretreatment viral load, pretreatment CD4 count, and with viral blips. In addition, the decay of the latent HIV-1 reservoir is in line with smaller studies using either viral outgrowth assays or total HIV-1 DNA17,19. Furthermore, if slopes were due to within-subject sample variability, a lower fraction of consistent within-subject increase/decrease would have been observed.

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